What is a Custom Vaccine?

Custom, or autogenous, vaccines are created to address specific disease management needs, for a specific operation, location or area, that are not being met by commercial vaccines. 

A custom vaccine is:

Regulated by the United States Department of Agriculture (USDA) Center for Veterinary Biologics

Produced according to an approved Outline of Production (9 CFR 113:113)

Approved only for use by or under the direction of a licensed veterinarian.

 

What Diseases Can a Custom Vaccine Address?

Common bacteria and viruses that can be addressed by the use of custom vaccines: 

  • Adenovirus

  • Astrovirus

  • Avian Influenza Virus*

  • Avian Reoviruses

  • Avibacterium   paragallinarum

  • Campylobacter

  • Gallibacterium 

  • Erysipelothrix rhusiopathiae

  • Escherichia Coli

  • Infectious Bronchitis Virus

  • Infectious Bursal Disease Virus 

  • Newcastle Disease Virus*

  • Ornithobacterium rhinotracheale

  • Paramyxovirus Type 3 

  • Pasteurella multocida

  • Rotavirus

  • Salmonella Species

  • Swine Influenza Virus

* Memo 800.103 compliant

 

Best Practice Isolate Selection

Ceva uses internal and external experts as well as classical and molecular techniques to ensure proper selection of the antigen to rapidly provide a targeted solution for your flock.

  • Epidemiology surveys

  • Whole genome sequencing

  • In-vitro/In-vivo pathogen characterization

  • Extensive Classical Bacteriology/Virology Analysis

  • Growth characterization

Qualification

Creating an Optimal Master Seed 

BACTERIAL

  • Master seed is propagated, harvested and undergoes testing

  • Purity testing

  • Identity confirmation via biochemical analysis

VIRAL

  • Tissue Culture: Master seed propagated to increase viral titer

  • Chicken Embryo Origin (CEO): Master seed adaption, viral titer build up and testing

  • Testing includes:
    -  Titration of virus in its preferred growth media

    -  Bacterial contamination plating/liquid media

Adjuvants

Creating an ideal Immune Response

Levels of adjuvant specified in the Outlines of Production

Water-in-Oil (WO)

  • Strong immune response

  • Possibility of post vaccination reactions

Oil-in-Water (OW)

  • Main adjuvant for custom bacterins 

  • Minimal post vaccination reactions

ENABL

  • Synthetic aqueous polymer (Lipid Polymer Matrix or LPM)

  • Stimulation of multiple immunological pathways

  • Very safe, non animal origin components

  • 21 day withdrawal period (lowest allowed by USDA)

  • Administered at room temperature

Vaccine Release

Ensuring the Safety of Your Flock

  • Vaccine serials must be tested for purity, safety and identification and Ceva submits forms and samples to USDA as required

  • Sample processing and QA & USDA release must occur prior to shipment

 
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Support to Protect the Flock

Ceva offers thorough diagnostic and investigative work to help your veterinary staff identify the unique needs of your flock.

Custom Disease Solutions

Ceva works with you to create optimal vaccines in order to manage the specific disease-causing pathogens circulating on your farm(s).

Rapid, Accurate Pathogen Identification

In order to help you achieve ideal protection, Ceva rapidly isolates and accurately identifies the etiological agents affecting your  flock. Through internal and external labs, Ceva thoroughly characterizes the pathogen to ensure the optimal isolates are chosen to vaccinate your flock.